Prof. Margaret Buckingham

Institut Pasteur, Paris


How embryonic cells acquire tissue identity is a central theme of developmental biology, which extends to the maintenance of stem cells for tissue repair in the adult. Margaret Buckingham has used the tools of mouse molecular genetics to investigate the genes that control entry into the myogenic programme in the embryo and that regulate stem cell behaviour in adult skeletal muscle. Much of her more recent research has focussed on the gene regulatory network controlled by Pax3 and Pax7, shown to play an essential upstream role in the formation of skeletal muscle. She also works on cardiogenesis, with the identification of the second heart field as a major source of cells for the formation of the mammalian heart.

Margaret Buckingham is an Emeritus Director of Research in the CNRS and Honorary Professor at the Pasteur Institute in Paris. She is a member of EMBO, the Academia Europaea, the French Académie des Sciences, the Royal Societies of London and Edinburgh and an associate member of the National Academy of Sciences, USA.

At Future Medicine 2017, her Keynote will be about "The behaviour of skeletal muscle stem cells"